LHX5 Antibody (monoclonal) (M10)
Mouse monoclonal antibody raised against a full length recombinant LHX5.
|Application ||WB, E|
|Calculated MW||44406 Da|
|Other Names||LIM/homeobox protein Lhx5, LIM homeobox protein 5, LHX5|
|Target/Specificity||LHX5 (NP_071758, 114 a.a. ~ 182 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||LHX5 Antibody (monoclonal) (M10) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in the control of differentiation and development of the forebrain. In mice, this protein is essential for the regulation of precursor cell proliferation and the control of neuronal differentiation and migration during hippocampal development. This protein is involved in learning and motor functions in adult mice.
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. Lowe JK, et al. PLoS Genet, 2009 Feb. PMID 19197348.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5. Green EK, et al. Psychiatr Genet, 2003 Jun. PMID 12782966.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.Learning impairments and motor dysfunctions in adult Lhx5-deficient mice displaying hippocampal disorganization. Paylor R, et al. Physiol Behav, 2001 Aug. PMID 11566211.
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