|Application ||WB, IF, E|
|Calculated MW||38492 Da|
|Other Names||Transcription factor Maf, Proto-oncogene c-Maf, V-maf musculoaponeurotic fibrosarcoma oncogene homolog, MAF|
|Target/Specificity||MAF (NP_005351, 304 a.a. ~ 403 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MAF Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families. Kim HN, et al. J Hum Genet, 2010 Jul 29. PMID 20668459.Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. Fontaine-Bisson B, et al. Diabetologia, 2010 Oct. PMID 20571754.SUMOylation attenuates c-Maf-dependent IL-4 expression. Lin BS, et al. Eur J Immunol, 2010 Apr. PMID 20127678.KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming. Hansen A, et al. Genes Dev, 2010 Jan 15. PMID 20080955.Transcriptional activation of human MMP-13 gene expression by c-Maf in osteoarthritic chondrocyte. Li T, et al. Connect Tissue Res, 2010. PMID 20067416.
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