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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MAPKAPK2 Antibody (monoclonal) (M01)   

MAPKAPK2 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant MAPKAPK2.

  • WB - MAPKAPK2 Antibody (monoclonal) (M01) AT2795a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
  • WB - MAPKAPK2 Antibody (monoclonal) (M01) AT2795a
    MAPKAPK2 monoclonal antibody (M01), clone 2B3 Western Blot analysis of MAPKAPK2 expression in K-562 ( (Cat # AT2795a )
  • IHC - MAPKAPK2 Antibody (monoclonal) (M01) AT2795a
    Immunoperoxidase of monoclonal antibody to MAPKAPK2 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml]
  • IF - MAPKAPK2 Antibody (monoclonal) (M01) AT2795a
    Immunofluorescence of monoclonal antibody to MAPKAPK2 on HeLa cell. [antibody concentration 10 ug/ml]
  • IP - MAPKAPK2 Antibody (monoclonal) (M01) AT2795a
    Immunoprecipitation of MAPKAPK2 transfected lysate using anti-MAPKAPK2 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with MAPKAPK2 MaxPab rabbit polyclonal antibody.
  • E - MAPKAPK2 Antibody (monoclonal) (M01) AT2795a
    Detection limit for recombinant GST tagged MAPKAPK2 is approximately 0.1ng/ml as a capture antibody.
  •  - MAPKAPK2 Antibody (monoclonal) (M01) AT2795a
    Proximity Ligation Analysis of protein-protein interactions between AKT1 and MAPKAPK2 HeLa cells were stained with anti-AKT1 rabbit purified polyclonal 1:1200 and anti-MAPKAPK2 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49137
Other Accession NM_032960
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 2B3
Calculated MW 45568 Da
Additional Information
Gene ID 9261
Other Names MAP kinase-activated protein kinase 2, MAPK-activated protein kinase 2, MAPKAP kinase 2, MAPKAP-K2, MAPKAPK-2, MK-2, MK2, MAPKAPK2
Target/Specificity MAPKAPK2 (NP_116584, 302 a.a. ~ 400 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsMAPKAPK2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.


TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. Gais P, et al. J Immunol, 2010 May 15. PMID 20375303.p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. Cannell IG, et al. Proc Natl Acad Sci U S A, 2010 Mar 23. PMID 20212154.MK2 signaling: lessons on tissue specificity in modulation of inflammation. Fyhrquist N, et al. J Invest Dermatol, 2010 Feb. PMID 20081887.p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Kumar B, et al. Cancer Res, 2010 Jan 15. PMID 20068172.The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response. Saenz JB, et al. Cell Microbiol, 2010 Apr 1. PMID 19951368.

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$ 315.00
Cat# AT2795a
(40 western blots)
Availability: 7-10 days
Bulk Size
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