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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MARCKS Antibody (monoclonal) (M04)   

MARCKS Antibody (monoclonal) (M04)

Mouse monoclonal antibody raised against a partial recombinant MARCKS.

  • WB - MARCKS Antibody (monoclonal) (M04) AT2802a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (32.78 KDa) .
  • WB - MARCKS Antibody (monoclonal) (M04) AT2802a
    MARCKS monoclonal antibody (M04), clone 2H4. Western Blot analysis of MARCKS expression in Raw 264.7 ( (Cat # AT2802a )
  • E - MARCKS Antibody (monoclonal) (M04) AT2802a
    Detection limit for recombinant GST tagged MARCKS is approximately 0.1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P29966
Other Accession NM_002356
Reactivity Human, Mouse
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2H4
Calculated MW 31555 Da
Additional Information
Gene ID 4082
Other Names Myristoylated alanine-rich C-kinase substrate, MARCKS, Protein kinase C substrate, 80 kDa protein, light chain, 80K-L protein, PKCSL, MARCKS, MACS, PRKCSL
Target/Specificity MARCKS (NP_002347, 2 a.a. ~ 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsMARCKS Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.


MARCKS and related chaperones bind to unconventional myosin V isoforms in airway epithelial cells. Lin KW, et al. Am J Respir Cell Mol Biol, 2010 Aug. PMID 20203291.Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway. Techasen A, et al. Cancer Sci, 2010 Mar. PMID 20047593.A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis. Finlayson AE, et al. PLoS One, 2009 Nov 18. PMID 19924305.Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression. Micallef J, et al. Cancer Res, 2009 Oct 1. PMID 19773446.Myristoylated alanine-rich C-kinase substrate (MARCKS) protein regulation of human neutrophil migration. Eckert RE, et al. Am J Respir Cell Mol Biol, 2010 May. PMID 19574534.

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$ 315.00
Cat# AT2802a
(40 western blots)
Availability: 7-10 days
Bulk Size
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