MBNL1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant MBNL1.
|Application ||WB, E|
|Calculated MW||41817 Da|
|Other Names||Muscleblind-like protein 1, Triplet-expansion RNA-binding protein, MBNL1, EXP, KIAA0428, MBNL|
|Target/Specificity||MBNL1 (AAH50535, 1 a.a. ~ 343 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MBNL1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. Sen S, et al. J Biol Chem, 2010 Aug 13. PMID 20519504.A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding. Arambula JF, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805260.Ribonuclear inclusions and MBNL1 nuclear sequestration do not affect myoblast differentiation but alter gene splicing in myotonic dystrophy type 2. Cardani R, et al. Neuromuscul Disord, 2009 May. PMID 19345584.Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle. Holt I, et al. Am J Pathol, 2009 Jan. PMID 19095965.Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Teplova M, et al. Nat Struct Mol Biol, 2008 Dec. PMID 19043415.
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