MSI1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a full length recombinant MSI1.
|Application ||WB, IHC, IF, E|
|Calculated MW||39125 Da|
|Other Names||RNA-binding protein Musashi homolog 1, Musashi-1, MSI1|
|Target/Specificity||MSI1 (NP_002433, 1 a.a. ~ 87 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MSI1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.
Expression of putative stem cell genes Musashi-1 and beta1-integrin in human colorectal adenomas and adenocarcinomas. Fan LF, et al. Int J Colorectal Dis, 2010 Jan. PMID 19714342.Genomic analyses of musashi1 downstream targets show a strong association with cancer-related processes. de Sousa Abreu R, et al. J Biol Chem, 2009 May 1. PMID 19258308.Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. Murayama M, et al. J Gastroenterol, 2009. PMID 19214660.Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy. Sanchez-Diaz PC, et al. BMC Cancer, 2008 Sep 30. PMID 18826648.Increased expression of the adult stem cell marker Musashi-1 in endometriosis and endometrial carcinoma. G?tte M, et al. J Pathol, 2008 Jul. PMID 18473332.
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