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MTF1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant MTF1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q14872 |
| Other Accession | NM_005955 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3G12 |
| Calculated MW | 80957 Da |
| Gene ID | 4520 |
|---|---|
| Other Names | Metal regulatory transcription factor 1, MRE-binding transcription factor, Transcription factor MTF-1, MTF1 |
| Target/Specificity | MTF1 (NP_005946, 41 a.a. ~ 140 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MTF1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).
References
Divalent metal-dependent regulation of hepcidin expression by MTF-1. Balesaria S, et al. FEBS Lett, 2010 Feb 19. PMID 20026331.Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor. Takamura M, et al. Int J Oncol, 2010 Jan. PMID 19956853.Metal transcription factor-1 regulation via MREs in the transcribed regions of selenoprotein H and other metal-responsive genes. Stoytcheva ZR, et al. Biochim Biophys Acta, 2010 Mar. PMID 19913599.Metal-responsive transcription factor 1 (MTF-1) activity is regulated by a nonconventional nuclear localization signal and a metal-responsive transactivation domain. Lindert U, et al. Mol Cell Biol, 2009 Dec. PMID 19797083.Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. Akulevich NM, et al. Endocr Relat Cancer, 2009 Jun. PMID 19286843.
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