MTF1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant MTF1.
|Application ||WB, E|
|Calculated MW||80957 Da|
|Other Names||Metal regulatory transcription factor 1, MRE-binding transcription factor, Transcription factor MTF-1, MTF1|
|Target/Specificity||MTF1 (NP_005946, 41 a.a. ~ 140 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||MTF1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).
Divalent metal-dependent regulation of hepcidin expression by MTF-1. Balesaria S, et al. FEBS Lett, 2010 Feb 19. PMID 20026331.Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor. Takamura M, et al. Int J Oncol, 2010 Jan. PMID 19956853.Metal transcription factor-1 regulation via MREs in the transcribed regions of selenoprotein H and other metal-responsive genes. Stoytcheva ZR, et al. Biochim Biophys Acta, 2010 Mar. PMID 19913599.Metal-responsive transcription factor 1 (MTF-1) activity is regulated by a nonconventional nuclear localization signal and a metal-responsive transactivation domain. Lindert U, et al. Mol Cell Biol, 2009 Dec. PMID 19797083.Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. Akulevich NM, et al. Endocr Relat Cancer, 2009 Jun. PMID 19286843.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.