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NEFH Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT3010a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
NEFH Antibody (monoclonal) (M01) - Product info | |
| Application | WB
|
| Primary Accession | P12036 |
| Other Accession | NP_066554 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 200000000 |
| Calculated MW | 112479 Da |
NEFH Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 4744 | |
| Other Names NFHneurofilament, heavy polypeptide 200kDa | |
| Target/Specificity NEFH (NP_066554, 263 a.a. ~ 364 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NEFH Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NEFH Antibody (monoclonal) (M01) - Application data
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NEFH monoclonal antibody (M01), clone 2E8 Western Blot analysis of NEFH expression in HeLa ( Cat # L013V1 ).
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Detection limit for recombinant GST tagged NEFH is approximately 0.03ng/ml as a capture antibody.
NEFH Antibody (monoclonal) (M01) - Related products
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BACKGROUND
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
REFERENCES
A genome-wide association study of carotid atherosclerosis in HIV-infected men. Shrestha S, et al. AIDS, 2010 Feb 20. PMID 20009918.Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders. Alberti C, et al. AIDS Res Hum Retroviruses, 2009 Aug. PMID 19678766.Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON). Guy J, et al. Mol Vis, 2008. PMID 19104679.Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. Greg?rio SP, et al. Psychiatry Res, 2009 Jan 30. PMID 19054571.Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. Rudrabhatla P, et al. J Biol Chem, 2008 Sep 26. PMID 18635547.
