NR0B1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant NR0B1.
|Application ||WB, IF, E|
|Calculated MW||51718 Da|
|Other Names||Nuclear receptor subfamily 0 group B member 1, DSS-AHC critical region on the X chromosome protein 1, Nuclear receptor DAX-1, NR0B1, AHC, DAX1|
|Target/Specificity||NR0B1 (NP_000466, 361 a.a. ~ 470 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NR0B1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis. Nedumaran B, et al. J Biol Chem, 2010 Mar 19. PMID 20080977.EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma. Kinsey M, et al. Cancer Res, 2009 Dec 1. PMID 19920188.X-linked congenital adrenal hypoplasia with hypogonadotropic hypogonadism caused by an inversion disrupting a conserved noncoding element upstream of the NR0B1 (DAX1) gene. Skinningsrud B, et al. J Clin Endocrinol Metab, 2009 Oct. PMID 19773398.Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells. Nagl F, et al. Am J Physiol Cell Physiol, 2009 Nov. PMID 19726747.A novel mutation in DAX1 (NR0B1) causing X-linked adrenal hypoplasia congenita: clinical, hormonal and genetic analysis. Garc?a-Malpartida K, et al. Endocrine, 2009 Oct. PMID 19672728.
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