NR4A2 Antibody (monoclonal) (M10)
Mouse monoclonal antibody raised against a partial recombinant NR4A2.
|Application ||WB, IF, E|
|Calculated MW||66591 Da|
|Other Names||Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor, NR4A2, NOT, NURR1, TINUR|
|Target/Specificity||NR4A2 (AAH66890, 71 a.a. ~ 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NR4A2 Antibody (monoclonal) (M10) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Replicated association of the NR4A3 gene with smoking behavior in schizophrenia and in bipolar disorder. Novak G, et al. Genes Brain Behav, 2010 Jul 24. PMID 20659174.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes. Fonseca F, et al. Mol Diagn Ther, 2010 Jun 1. PMID 20560679.Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation. Bonta PI, et al. Circulation, 2010 May 11. PMID 20421523.Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival. Lee HS, et al. Stem Cells, 2010 Mar 31. PMID 20049900.
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