NUDT2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant NUDT2.
|Application ||WB, E|
|Calculated MW||16829 Da|
|Other Names||Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], Diadenosine 5', 5'''-P1, P4-tetraphosphate asymmetrical hydrolase, Ap4A hydrolase, Ap4Aase, Diadenosine tetraphosphatase, Nucleoside diphosphate-linked moiety X motif 2, Nudix motif 2, NUDT2, APAH1|
|Target/Specificity||NUDT2 (AAH04926, 1 a.a. ~ 147 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||NUDT2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified.
1.Nudix-type motif 2 (NUDT2) in human breast carcinoma: A potent prognostic factor associated with cell proliferation.Oka K, Suzuki T, Onodera Y, Miki Y, Takagi K, Nagasaki S, Akahira JI, Ishida T, Watanabe M, Hirakawa H, Ohuchi N, Sasano H.Int J Cancer. 2010 Jun 9. [Epub ahead of print]
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