ODC1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant ODC1.
|Application ||WB, IF|
|Calculated MW||51148 Da|
|Other Names||Ornithine decarboxylase, ODC, ODC1|
|Target/Specificity||ODC1 (AAH25296, 1 a.a. ~ 461 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||ODC1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
Ornithine Decarboxylase-1 Polymorphism, Chemoprevention With Eflornithine and Sulindac, and Outcomes Among Colorectal Adenoma Patients. Zell JA, et al. J Natl Cancer Inst, 2010 Aug 26. PMID 20798393.Ornithine Decarboxylase G316A Genotype and Colorectal Cancer Risk. Hughes D, et al. Colorectal Dis, 2010 Apr 29. PMID 20456464.Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer. Grimminger PP, et al. Clin Lung Cancer, 2010 Mar 1. PMID 20199977.The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. Geerts D, et al. Int J Cancer, 2010 May 1. PMID 19960435.Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. Zell JA, et al. Clin Cancer Res, 2009 Oct 1. PMID 19789310.
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