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OXSR1 Antibody (monoclonal) (M16)
Mouse monoclonal antibody raised against a full length recombinant OXSR1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | O95747 |
| Other Accession | BC008726.1 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3A8 |
| Calculated MW | 58022 Da |
| Gene ID | 9943 |
|---|---|
| Other Names | Serine/threonine-protein kinase OSR1, Oxidative stress-responsive 1 protein, OXSR1 (HGNC:8508) |
| Target/Specificity | OXSR1 (AAH08726.1, 1 a.a. ~ 527 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | OXSR1 Antibody (monoclonal) (M16) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
References
Crystal structure of domain-swapped STE20 OSR1 kinase domain. Lee SJ, et al. Protein Sci, 2009 Feb. PMID 19177573.Structure of the OSR1 kinase, a hypertension drug target. Villa F, et al. Proteins, 2008 Dec. PMID 18831043.Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. Richardson C, et al. J Cell Sci, 2008 Mar 1. PMID 18270262.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Structural insights into the recognition of substrates and activators by the OSR1 kinase. Villa F, et al. EMBO Rep, 2007 Sep. PMID 17721439.
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