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PAX7 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant PAX7.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P23759 |
| Other Accession | NM_002584 |
| Reactivity | Human, Mouse |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1.0E+12 |
| Calculated MW | 55119 Da |
| Gene ID | 5081 |
|---|---|
| Other Names | Paired box protein Pax-7, HuP1, PAX7, HUP1 |
| Target/Specificity | PAX7 (NP_002575.1, 411 a.a. ~ 520 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PAX7 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.
References
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma. Williamson D, et al. J Clin Oncol, 2010 May 1. PMID 20351326.Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Edwards TL, et al. Ann Hum Genet, 2010 Mar. PMID 20070850.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.Maternal transmission effects of the PAX genes among cleft case-parent trios from four populations. Sull JW, et al. Eur J Hum Genet, 2009 Jun. PMID 19142206.
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