PAX7 Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant PAX7.
|Application ||WB, IF, E|
|Calculated MW||55119 Da|
|Other Names||Paired box protein Pax-7, HuP1, PAX7, HUP1|
|Target/Specificity||PAX7 (NP_002575.1, 411 a.a. ~ 520 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PAX7 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.
An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Shimada M, et al. Hum Genet, 2010 Oct. PMID 20677014.Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma. Williamson D, et al. J Clin Oncol, 2010 May 1. PMID 20351326.Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Edwards TL, et al. Ann Hum Genet, 2010 Mar. PMID 20070850.High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, et al. J Bone Miner Res, 2009 Dec. PMID 19453261.Maternal transmission effects of the PAX genes among cleft case-parent trios from four populations. Sull JW, et al. Eur J Hum Genet, 2009 Jun. PMID 19142206.
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