PCGF2 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant PCGF2.
|Calculated MW||37788 Da|
|Other Names||Polycomb group RING finger protein 2, DNA-binding protein Mel-18, RING finger protein 110, Zinc finger protein 144, PCGF2, MEL18, RNF110, ZNF144|
|Target/Specificity||PCGF2 (AAH04858.1, 236 a.a. ~ 294 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PCGF2 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer. Zhang XW, et al. Mol Cancer, 2010 Feb 21. PMID 20170541.The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance. Wang W, et al. Int J Cancer, 2009 Dec 15. PMID 19585577.Mel-18 interacts with RanGAP1 and inhibits its sumoylation. Zhang J, et al. Biochem Biophys Res Commun, 2008 Oct 17. PMID 18706886.A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin. Elderkin S, et al. Mol Cell, 2007 Oct 12. PMID 17936708.Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. Szafranski K, et al. Genome Biol, 2007. PMID 17672918.
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