PDCD6 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PDCD6.
|Application ||WB, IF, E|
|Calculated MW||21868 Da|
|Other Names||Programmed cell death protein 6, Apoptosis-linked gene 2 protein, Probable calcium-binding protein ALG-2, PDCD6, ALG2|
|Target/Specificity||PDCD6 (AAH12384, 92 a.a. ~ 191 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PDCD6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.
Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1. Vergarajauregui S, et al. J Biol Chem, 2009 Dec 25. PMID 19864416.Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101. Okumura M, et al. Biochem Biophys Res Commun, 2009 Aug 14. PMID 19520058.Crystallization and X-ray diffraction analysis of N-terminally truncated human ALG-2. Suzuki H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Nov 1. PMID 18997320.Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples. Yamada Y, et al. Cancer Sci, 2008 Nov. PMID 18957060.Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism. Suzuki H, et al. Structure, 2008 Oct 8. PMID 18940611.
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