PDE1B Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PDE1B.
|Application ||WB, E|
|Calculated MW||61380 Da|
|Other Names||Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1B, Cam-PDE 1B, 63 kDa Cam-PDE, PDE1B, PDE1B1, PDES1B|
|Target/Specificity||PDE1B (AAH32226, 437 a.a. ~ 536 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PDE1B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been classified into several families based on their biochemical properties. Members of the PDE1 family, such as PDE1B, are calmodulin (see MIM 114180)-dependent PDEs (CaM-PDEs) that are stimulated by a calcium-calmodulin complex (Repaske et al., 1992 [PubMed 1326532]).
1.Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4(+) T cells.Bazhin AV, Kahnert S, Kimpfler S, Schadendorf D, Umansky V.Mol Immunol. 2009 Nov 23. [Epub ahead of print]
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