PGEA1 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant CBY1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9Y3M2 |
Other Accession | NM_015373 |
Reactivity | Human |
Host | mouse |
Clonality | Monoclonal |
Isotype | IgG1 Kappa |
Clone Names | 2F2 |
Calculated MW | 14470 Da |
Gene ID | 25776 |
---|---|
Other Names | Protein chibby homolog 1, ARPP-binding protein, Cytosolic leucine-rich protein, PIGEA-14, PKD2 interactor, Golgi and endoplasmic reticulum-associated 1, CBY1, ARB1, C22orf2, CBY, PGEA1 |
Target/Specificity | CBY1 (NP_056188, 18 a.a. ~ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | PGEA1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.
References
Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma. Vandepoele K, et al. Exp Cell Res, 2010 Apr 15. PMID 20096688.Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling. Li FQ, et al. Mol Biol Cell, 2010 Jan 15. PMID 19940019.Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. Menon R, et al. Reprod Biol Endocrinol, 2009 Jun 15. PMID 19527514.Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif. Mofunanya A, et al. BMC Mol Biol, 2009 May 12. PMID 19435523.Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. Velez DR, et al. Am J Obstet Gynecol, 2009 Feb. PMID 19019335.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.