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PGEA1 Antibody (monoclonal) (M06)

Mouse monoclonal antibody raised against a partial recombinant CBY1.

     
  • WB - PGEA1 Antibody (monoclonal) (M06) AT3280a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.73 KDa) .
  • WB - PGEA1 Antibody (monoclonal) (M06) AT3280a
    Western Blot analysis of CBY1 expression in transfected 293T cell line by CBY1 monoclonal antibody (M06), clone 2F2.

    Lane 1: CBY1 transfected lysate (Predicted MW: 14.5 KDa).
    Lane 2: Non-transfected lysate.
  • E - PGEA1 Antibody (monoclonal) (M06) AT3280a
    Detection limit for recombinant GST tagged CBY1 is approximately 0.1ng/ml as a capture antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y3M2
Other Accession NM_015373
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2F2
Calculated MW 14470 Da
Additional Information
Gene ID 25776
Other Names Protein chibby homolog 1, ARPP-binding protein, Cytosolic leucine-rich protein, PIGEA-14, PKD2 interactor, Golgi and endoplasmic reticulum-associated 1, CBY1, ARB1, C22orf2, CBY, PGEA1
Target/Specificity CBY1 (NP_056188, 18 a.a. ~ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsPGEA1 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Background

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.

References

Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma. Vandepoele K, et al. Exp Cell Res, 2010 Apr 15. PMID 20096688.Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling. Li FQ, et al. Mol Biol Cell, 2010 Jan 15. PMID 19940019.Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. Menon R, et al. Reprod Biol Endocrinol, 2009 Jun 15. PMID 19527514.Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif. Mofunanya A, et al. BMC Mol Biol, 2009 May 12. PMID 19435523.Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. Velez DR, et al. Am J Obstet Gynecol, 2009 Feb. PMID 19019335.

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$ 315.00
Cat# AT3280a
Size:
Quantity:
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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