PGGT1B Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant PGGT1B.
|Application ||WB, IHC, IF, E|
|Calculated MW||42368 Da|
|Other Names||Geranylgeranyl transferase type-1 subunit beta, Geranylgeranyl transferase type I subunit beta, GGTase-I-beta, Type I protein geranyl-geranyltransferase subunit beta, PGGT1B|
|Target/Specificity||PGGT1B (NP_005014, 1 a.a. ~ 105 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PGGT1B Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.
1.Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes.Lee R, Chang SY, Trinh H, Tu Y, White AC, Davies BS, Bergo MO, Fong LG, Lowry WE, Young SG.Hum Mol Genet. 2010 Feb 11. [Epub ahead of print]
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