PGR Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant PGR. This PGR gene uses two distinct
|Application ||WB, IHC, IF, E|
|Calculated MW||98981 Da|
|Other Names||Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3|
|Target/Specificity||PGR (NP_000917, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PGR Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.
1.Major Functional Transcriptome of an Inferred Center Regulator of an ER(-) Breast Cancer Model System.Liu LY, Chang LY, Kuo WH, Hwa HL, Lin YS, Huang SF, Chen CN, Chang KJ, Hsieh FJ.Cancer Inform. 2012;11:87-111. Epub 2012 Apr 19.2.In Silico Prediction for Regulation of Transcription Factors onTheir Shared Target Genes Indicates Relevant Clinical Implications in a Breast Cancer Population.Liu LY, Chang LY, Kuo WH, Hwa HL, Shyu MK, Chang KJ, Hsieh FJ.Cancer Inform. 2012;11:113-37. Epub 2012 Apr 19.
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