PGR Antibody (monoclonal) (M08)
Mouse monoclonal antibody raised against a partial recombinant PGR. This PGR gene uses two distinct
|Application ||WB, IHC, IF, E|
|Calculated MW||98981 Da|
|Other Names||Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3|
|Target/Specificity||PGR (NP_000917, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PGR Antibody (monoclonal) (M08) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform A has not been clearly determined.
1.Comparison of estrogenic responses in bone and uterus depending on the parity status in Lewis rats.Keiler AM, Bernhardt R, Scharnweber D, Jarry H, Vollmer G, Zierau O.J Steroid Biochem Mol Biol. 2012 Sep 29. pii: S0960-0760(12)00189-6. doi: 10.1016/j.jsbmb.2012.09.023.
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