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PLEKHG5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PLEKHG5.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | O94827 |
| Other Accession | NM_020631 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5A9 |
| Calculated MW | 111231 Da |
| Gene ID | 57449 |
|---|---|
| Other Names | Pleckstrin homology domain-containing family G member 5, PH domain-containing family G member 5, Guanine nucleotide exchange factor 720, GEF720, PLEKHG5, KIAA0720 |
| Target/Specificity | PLEKHG5 (NP_065682, 896 a.a. ~ 995 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PLEKHG5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Multations in this gene have been found in a family with distal spinal muscular atrophy.
References
1.Phosphorylation-mediated 14-3-3 Protein Binding Regulates the Function of the Rho-specific Guanine Nucleotide Exchange Factor (RhoGEF) Syx.Ngok SP, Geyer R, Kourtidis A, Storz P, Anastasiadis PZJ Biol Chem. 2013 Mar 1;288(9):6640-50. doi: 10.1074/jbc.M112.432682. Epub 2013 Jan 18.2.VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.Ngok SP, Geyer R, Liu M, Kourtidis A, Agrawal S, Wu C, Seerapu HR, Lewis-Tuffin LJ, Moodie KL, Huveldt D, Marx R, Baraban JM, Storz P, Horowitz A, Anastasiadis PZ.J Cell Biol. 2012 Dec 24;199(7):1103-15. doi: 10.1083/jcb.201207009. Epub 2012 Dec 17.
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