PLP1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant PLP1.
|Application ||WB, E|
|Calculated MW||30077 Da|
|Other Names||Myelin proteolipid protein, PLP, Lipophilin, PLP1, PLP|
|Target/Specificity||PLP1 (NP_000524, 177 a.a. ~ 232 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PLP1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
Developmental and degenerative features in a complicated spastic paraplegia. Manzini MC, et al. Ann Neurol, 2010 Apr. PMID 20437587.Magnetic resonance imaging of a unique mutation in a family with Pelizaeus-Merzbacher disease. Miller E, et al. Am J Med Genet A, 2010 Mar. PMID 20186781.Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene. Sarret C, et al. Neuroscience, 2010 Mar 17. PMID 20036320.Hereditary spastic paraplegia caused by the PLP1 'rumpshaker mutation'. Svenstrup K, et al. J Neurol Neurosurg Psychiatry, 2010 Jun. PMID 19955111.Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein. Roboti P, et al. J Cell Sci, 2009 Nov 1. PMID 19825935.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.