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PLP1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant PLP1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P60201 |
| Other Accession | NM_000533 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4H8 |
| Calculated MW | 30077 Da |
| Gene ID | 5354 |
|---|---|
| Other Names | Myelin proteolipid protein, PLP, Lipophilin, PLP1, PLP |
| Target/Specificity | PLP1 (NP_000524, 177 a.a. ~ 232 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PLP1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
References
Developmental and degenerative features in a complicated spastic paraplegia. Manzini MC, et al. Ann Neurol, 2010 Apr. PMID 20437587.Magnetic resonance imaging of a unique mutation in a family with Pelizaeus-Merzbacher disease. Miller E, et al. Am J Med Genet A, 2010 Mar. PMID 20186781.Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene. Sarret C, et al. Neuroscience, 2010 Mar 17. PMID 20036320.Hereditary spastic paraplegia caused by the PLP1 'rumpshaker mutation'. Svenstrup K, et al. J Neurol Neurosurg Psychiatry, 2010 Jun. PMID 19955111.Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein. Roboti P, et al. J Cell Sci, 2009 Nov 1. PMID 19825935.
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