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PLP1 Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant PLP1.

  • WB - PLP1 Antibody (monoclonal) (M05) AT3346a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (31.9 KDa) .
  • E - PLP1 Antibody (monoclonal) (M05) AT3346a
    Detection limit for recombinant GST tagged PLP1 is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P60201
Other Accession NM_000533
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4H8
Calculated MW 30077 Da
Additional Information
Gene ID 5354
Other Names Myelin proteolipid protein, PLP, Lipophilin, PLP1, PLP
Target/Specificity PLP1 (NP_000524, 177 a.a. ~ 232 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsPLP1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.


Developmental and degenerative features in a complicated spastic paraplegia. Manzini MC, et al. Ann Neurol, 2010 Apr. PMID 20437587.Magnetic resonance imaging of a unique mutation in a family with Pelizaeus-Merzbacher disease. Miller E, et al. Am J Med Genet A, 2010 Mar. PMID 20186781.Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene. Sarret C, et al. Neuroscience, 2010 Mar 17. PMID 20036320.Hereditary spastic paraplegia caused by the PLP1 'rumpshaker mutation'. Svenstrup K, et al. J Neurol Neurosurg Psychiatry, 2010 Jun. PMID 19955111.Differences in endoplasmic-reticulum quality control determine the cellular response to disease-associated mutants of proteolipid protein. Roboti P, et al. J Cell Sci, 2009 Nov 1. PMID 19825935.

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$ 315.00
Cat# AT3346a
(40 western blots)
Availability: 7-10 days
Bulk Size
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