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PRKAR2A Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT3430a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
PRKAR2A Antibody (monoclonal) (M01) - Product info | |
| Application | WB
|
| Primary Accession | P13861 |
| Reactivity | Human |
| Isotype | IgG1 Kappa |
| Clone Names | 6A9 |
| Calculated MW | 45518 Da |
PRKAR2A Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 5576 | |
| Other Names MGC3606, PKR2, PRKAR2protein kinase, cAMP-dependent, regulatory, type II, alpha | |
| Target/Specificity PRKAR2A (AAH02763, 1 a.a. ~ 105 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions PRKAR2A Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
PRKAR2A Antibody (monoclonal) (M01) - Related products
AP6823a: PRKAR2A Antibody (N-term)
AP6823c: PRKAR2A Antibody (Center)
AP8096a: PKA R2 (PKR2) Antibody (N-term)
RI14218: PRKAR2A predesign siRNA
DC01098: Human PRKAR2A cDNA Clone
LY10107a: PRKAR2A Over-expression Lysate
BP6823a: PRKAR2A Antibody (N-term) Blocking Peptide
BP6823c: PRKAR2A Antibody (Center) Blocking Peptide
PRKAR2A Antibody (monoclonal) (M01) - Application data
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PRKAR2A monoclonal antibody (M01), clone 6A9 Western Blot analysis of PRKAR2A expression in HeLa ( Cat # L013V1 ).
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Detection limit for recombinant GST tagged PRKAR2A is approximately 0.03ng/ml as a capture antibody.
PRKAR2A Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).
REFERENCES
Biological Pathway-Based Genome-Wide Association Analysis Identified the Vasoactive Intestinal Peptide (VIP) Pathway Important for Obesity. Liu YJ, et al. Obesity (Silver Spring), 2010 Apr 8. PMID 20379146.Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. So HC, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jan 5. PMID 19367581.Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A and exchange protein activated by cyclic AMP pathways. Yeager LA, et al. Infect Immun, 2009 Jun. PMID 19307216.Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Martin BR, et al. Chem Biol, 2007 Sep. PMID 17884635.Anchoring of protein kinase A-regulatory subunit IIalpha to subapically positioned centrosomes mediates apical bile canalicular lumen development in response to oncostatin M but not cAMP. Wojtal KA, et al. Mol Biol Cell, 2007 Jul. PMID 17494870.
