PRKCA Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PRKCA.
|Application ||WB, IHC, IF, E|
|Calculated MW||76750 Da|
|Other Names||Protein kinase C alpha type, PKC-A, PKC-alpha, PRKCA, PKCA, PRKACA|
|Target/Specificity||PRKCA (NP_002728, 563 a.a. ~ 672 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PRKCA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
Analyses of shared genetic factors between asthma and obesity in children. Mel?n E, et al. J Allergy Clin Immunol, 2010 Sep. PMID 20816195.[The clinical signifcance of expression of ERCC1 and PkCalpha in non-small cell lung cancer] He L, et al. Zhongguo Fei Ai Za Zhi, 2010 Mar. PMID 20673527.Erk1/2-dependent phosphorylation of PKCalpha at threonine 638 in hippocampal 5-HT(1A) receptor-mediated signaling. Debata PR, et al. Biochem Biophys Res Commun, 2010 Jul 2. PMID 20513439.A Large-scale genetic association study of esophageal adenocarcinoma risk. Liu CY, et al. Carcinogenesis, 2010 Jul. PMID 20453000.PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells. Chiang CW, et al. J Biomed Sci, 2010 May 6. PMID 20444294.
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