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PRRX2 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant PRRX2.

     
  • WB - PRRX2 Antibody (monoclonal) (M01) AT3445a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.07 KDa) .
    detail
  • WB - PRRX2 Antibody (monoclonal) (M01) AT3445a
    Western Blot analysis of PRRX2 expression in transfected 293T cell line by PRRX2 monoclonal antibody (M01), clone 4C9.

    Lane 1: PRRX2 transfected lysate(27.1 KDa).
    Lane 2: Non-transfected lysate.
    detail
  • E - PRRX2 Antibody (monoclonal) (M01) AT3445a
    Detection limit for recombinant GST tagged PRRX2 is 0.1 ng/ml as a capture antibody.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99811
Other Accession NM_016307
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 4C9
Calculated MW 27079 Da
Additional Information
Gene ID 51450
Other Names Paired mesoderm homeobox protein 2, Paired-related homeobox protein 2, PRX-2, PRRX2, PMX2, PRX2
Target/Specificity PRRX2 (NP_057391.1, 151 a.a. ~ 253 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsPRRX2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)
citation

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Background

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.

References

Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Oxidation of Prx2 and phosphorylation of GRP58 by angiotensin II in human coronary smooth muscle cells identified by 2D-DIGE analysis. Tokutomi Y, et al. Biochem Biophys Res Commun, 2007 Dec 28. PMID 17964282.The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Wissm?ller S, et al. Nucleic Acids Res, 2006. PMID 16582099.A new translocation t(9;11)(q34;p15) fuses NUP98 to a novel homeobox partner gene, PRRX2, in a therapy-related acute myeloid leukemia. Gervais C, et al. Leukemia, 2005 Jan. PMID 15496970.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

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$ 350.00
Cat# AT3445a
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