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PURA Antibody (monoclonal) (M05)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT3502a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
PURA Antibody (monoclonal) (M05) - Product info | |
| Application | WB
|
| Primary Accession | Q00577 |
| Other Accession | NP_005850 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 3A9 |
| Calculated MW | 34911 Da |
PURA Antibody (monoclonal) (M05) - Additional info | |
| Gene ID 5813 | |
| Other Names PUR-ALPHA, PUR1, PURALPHApurine-rich element binding protein A | |
| Target/Specificity PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions PURA Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. | |
PURA Antibody (monoclonal) (M05) - Related products
AP11789b: PURA Antibody (C-term)
PURA Antibody (monoclonal) (M05) - Application data
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PURA monoclonal antibody (M05), clone 3A9. Western Blot analysis of PURA expression in PC-12 ( Cat # L012V1 ).
PURA Antibody (monoclonal) (M05) - Research Areas
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BACKGROUND
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
REFERENCES
Purine-rich element binding protein (PUR) alpha induces endoplasmic reticulum stress response, and cell differentiation pathways in prostate cancer cells. Inoue T, et al. Prostate, 2009 Jun 1. PMID 19267365.Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.Protective role of Puralpha to cisplatin. Kaminski R, et al. Cancer Biol Ther, 2008 Dec. PMID 18927497.Negative regulation of AbetaPP gene expression by pur-alpha. Darbinian N, et al. J Alzheimers Dis, 2008 Sep. PMID 18780968.Androgen receptor overexpression in prostate cancer linked to Pur alpha loss from a novel repressor complex. Wang LG, et al. Cancer Res, 2008 Apr 15. PMID 18413735.
