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RASGRP4 Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AT3580a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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RASGRP4 Antibody (monoclonal) (M01) - Product info | |
| Primary Accession | - |
| Other Accession | NP_733748 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 1F3 |
RASGRP4 Antibody (monoclonal) (M01) - Additional info | |
| Other Names RAS guanyl releasing protein 4 | |
| Target/Specificity RASGRP4 (NP_733748, 574 a.a. ~ 674 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions RASGRP4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
RASGRP4 Antibody (monoclonal) (M01) - Application data
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Immunoperoxidase of monoclonal antibody to RASGRP4 ( Cat # AT3580a ) on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]
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Detection limit for recombinant GST tagged RASGRP4 is approximately 0.3ng/ml as a capture antibody.
RASGRP4 Antibody (monoclonal) (M01) - Related products
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BACKGROUND
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. [provided by RefSeq]