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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RASGRP4 Antibody (monoclonal) (M01)   

RASGRP4 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant RASGRP4.

  • WB - RASGRP4 Antibody (monoclonal) (M01) AT3580a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • IHC - RASGRP4 Antibody (monoclonal) (M01) AT3580a
    Immunoperoxidase of monoclonal antibody to RASGRP4 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3 ug/ml]
  • E - RASGRP4 Antibody (monoclonal) (M01) AT3580a
    Detection limit for recombinant GST tagged RASGRP4 is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TDF6
Other Accession NM_170603
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 1F3
Calculated MW 74882 Da
Additional Information
Gene ID 115727
Other Names RAS guanyl-releasing protein 4, RASGRP4
Target/Specificity RASGRP4 (NP_733748, 574 a.a. ~ 673 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsRASGRP4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. [provided by RefSeq]


1.Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras.Shalom-Feuerstein R, Makovski V, Levy R, Raz A, Kloog Y.Biochim Biophys Acta. 2008 Jun;1783(6):985-93. Epub 2008 Mar 25.

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$ 315.00
Cat# AT3580a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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