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RBBP6 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant RBBP6.

     
  • IF - RBBP6 Antibody (monoclonal) (M01) AT3588a
    Immunofluorescence of monoclonal antibody to RBBP6 on HeLa cell . [antibody concentration 10 ug/ml]
    detail
  • WB - RBBP6 Antibody (monoclonal) (M01) AT3588a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .
    detail
  • IHC - RBBP6 Antibody (monoclonal) (M01) AT3588a
    Immunoperoxidase of monoclonal antibody to RBBP6 on formalin-fixed paraffin-embedded human testis. [antibody concentration 3 ug/ml]
    detail
  • E - RBBP6 Antibody (monoclonal) (M01) AT3588a
    Detection limit for recombinant GST tagged RBBP6 is approximately 0.1ng/ml as a capture antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC, IF, E
Primary Accession Q7Z6E9
Other Accession NM_006910
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 5A11
Calculated MW 201564 Da
Additional Information
Gene ID 5930
Other Names E3 ubiquitin-protein ligase RBBP6, 632-, Proliferation potential-related protein, Protein P2P-R, Retinoblastoma-binding Q protein 1, RBQ-1, Retinoblastoma-binding protein 6, p53-associated cellular protein of testis, RBBP6, P2PR, PACT, RBQ1
Target/Specificity RBBP6 (NP_008841, 1582 a.a. ~ 1691 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsRBBP6 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)
citation

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Background

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

References

Voxelwise genome-wide association study (vGWAS). Stein JL, et al. Neuroimage, 2010 Nov 15. PMID 20171287.RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. Chibi M, et al. J Mol Biol, 2008 Dec 26. PMID 18851979.Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398.PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Li L, et al. Proc Natl Acad Sci U S A, 2007 May 8. PMID 17470788.Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983.

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$ 350.00
Cat# AT3588a
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