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RELA Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT3616a | 50 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
RELA Antibody (monoclonal) (M01) - Product info | |
| Application | IF, WB
|
| Primary Accession | Q04206 |
| Other Accession | NP_068810 |
| Reactivity | Human |
| Concentration | 0.5 mg/ml |
| Isotype | IgG1 Lambda |
| Clone Names | 8G3 |
| Calculated MW | 60219 Da |
RELA Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 5970 | |
| Other Names MGC131774, NFKB3v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | |
| Target/Specificity RELA (NP_068810, 432 a.a. ~ 506 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions RELA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
RELA Antibody (monoclonal) (M01) - Related products
AP3176a: Phospho-NFKBp65-S536 Antibody
AP3178a: Phospho-NFKB-S536 Antibody
AP3717a: Phospho-NF kappa B-S276 Antibody
AP3749a: Phospho-NF kappa B-S536 Antibody
AP6826a: RELA Antibody (N-term)
AP6826c: RELA Antibody (Center)
DC03759: Human RELA cDNA Clone
LY10116a: RELA Over-expression Lysate
BP3176a: Phospho-NFKBp65-S536 Antibody Blocking Peptide
BP3178a: Phospho-NFKB-pS536 Antibody Blocking Peptide
BP3717a: Phospho-NF kappa B-S276 Antibody Blocking Peptide
BP6826a: RELA Antibody (N-term) Blocking Peptide
BP6826c: RELA Antibody (Center) Blocking Peptide
BP9125c: NF kappa B-S276 Antibody Blocking Peptide
RELA Antibody (monoclonal) (M01) - Application data
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Immunofluorescence of monoclonal antibody to RELA (AT3616a) on HeLa cell . [antibody concentration 35 ug/ml]
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RELA monoclonal antibody (M01), clone 8G3 Western Blot analysis of RELA expression in HeLa NE ( Cat # L013V3 ).
RELA Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
REFERENCES
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Involvement of the p65/RelA subunit of NF-kappaB in TNF-alpha-induced SIRT1 expression in vascular smooth muscle cells. Zhang HN, et al. Biochem Biophys Res Commun, 2010 Jul 2. PMID 20617556.Dichotomy in NF-kappaB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering. Tromp JM, et al. Oncogene, 2010 Sep 9. PMID 20581863.Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer. Annunziata CM, et al. Cancer, 2010 Jul 1. PMID 20564628.Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. Jutooru I, et al. J Biol Chem, 2010 Aug 13. PMID 20538607.
