REPS2 Antibody (monoclonal) (M01A)
Mouse monoclonal antibody raised against a partial recombinant REPS2.
|Calculated MW||71534 Da|
|Other Names||RalBP1-associated Eps domain-containing protein 2, Partner of RalBP1, RalBP1-interacting protein 2, REPS2, POB1|
|Target/Specificity||REPS2 (NP_004717, 66 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||REPS2 Antibody (monoclonal) (M01A) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
TMEM25, REPS2 and Meis 1: favourable prognostic and predictive biomarkers for breast cancer. Doolan P, et al. Tumour Biol, 2009. PMID 19776672.Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. Singhal SS, et al. J Biol Chem, 2008 Jul 11. PMID 18474607.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Yadav S, et al. Biochem Biophys Res Commun, 2005 Mar 25. PMID 15707977.EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2. Oosterhoff JK, et al. Int J Cancer, 2005 Feb 10. PMID 15455380.
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