Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
REPS2 Antibody (monoclonal) (M01A)
Mouse monoclonal antibody raised against a partial recombinant REPS2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q8NFH8 |
| Other Accession | NM_004726 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgM Kappa |
| Clone Names | 4C2 |
| Calculated MW | 71534 Da |
| Gene ID | 9185 |
|---|---|
| Other Names | RalBP1-associated Eps domain-containing protein 2, Partner of RalBP1, RalBP1-interacting protein 2, REPS2, POB1 |
| Target/Specificity | REPS2 (NP_004717, 66 a.a. ~ 165 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | REPS2 Antibody (monoclonal) (M01A) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.
References
TMEM25, REPS2 and Meis 1: favourable prognostic and predictive biomarkers for breast cancer. Doolan P, et al. Tumour Biol, 2009. PMID 19776672.Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. Singhal SS, et al. J Biol Chem, 2008 Jul 11. PMID 18474607.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Yadav S, et al. Biochem Biophys Res Commun, 2005 Mar 25. PMID 15707977.EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2. Oosterhoff JK, et al. Int J Cancer, 2005 Feb 10. PMID 15455380.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
