RGS2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant RGS2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC, E |
---|---|
Primary Accession | P41220 |
Other Accession | BC007049 |
Reactivity | Human |
Host | mouse |
Clonality | Monoclonal |
Isotype | IgG2a Kappa |
Clone Names | 4C4 |
Calculated MW | 24382 Da |
Gene ID | 5997 |
---|---|
Other Names | Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8 |
Target/Specificity | RGS2 (AAH07049, 111 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | RGS2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.
References
1.Semi-quantitative measurement of specific proteins in human cumulus cells using reverse phase protein array.Puard V, Tranchant T, Cadoret V, Gauthier C, Reiter E, Guerif F, Royere DReprod Biol Endocrinol. 2013 Oct 22;11(1):100.2.Role of JAK2-STAT3 in TLR2-mediated tissue factor expression.Park DW, Lyu JH, Kim JS, Chin H, Bae YS, Baek SH.J Cell Biochem. 2012 Dec 13. doi: 10.1002/jcb.24472.3.RGS2 is a negative regulator of STAT3-mediated Nox1 expression.Lee HK, Park DW, Bae JH, Kim HJ, Shin DG, Park JS, Lee JG, Lee SJ, Bae YS, Baek SH.Cell Signal. 2011 Nov 18.4.Chromatin modifications induced by PML-RAR{alpha} repress critical targets in leukemogenesis as analyzed by ChIP-Chip.Hoemme C, Peerzada A, Behre G, Wang Y, McClelland M, Nieselt K, Zschunke M, Disselhoff C, Agrawal S, Isken F, Tidow N, Berdel WE, Serve H, Muller-Tidow C.Blood. 2008 Mar 1;111(5):2887-95. Epub 2007 Nov 16.
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