RIN2 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant RIN2.
|Application ||WB, E|
|Calculated MW||100163 Da|
|Other Names||Ras and Rab interactor 2, Ras association domain family 4, Ras inhibitor JC265, Ras interaction/interference protein 2, RIN2, RASSF4|
|Target/Specificity||RIN2 (NP_061866, 786 a.a. ~ 894 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||RIN2 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family.
The RIN2 syndrome: a new autosomal recessive connective tissue disorder caused by deficiency of Ras and Rab interactor 2 (RIN2). Syx D, et al. Hum Genet, 2010 Jul. PMID 20424861.RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome. Basel-Vanagaite L, et al. Am J Hum Genet, 2009 Aug. PMID 19631308.Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin. Kimura T, et al. J Biol Chem, 2006 Apr 14. PMID 16423831.Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. Kajiho H, et al. J Cell Sci, 2003 Oct 15. PMID 12972505.
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