RNF41 Antibody (monoclonal) (M01A)
Mouse monoclonal antibody raised against a partial recombinant RNF41.
|Calculated MW||35905 Da|
|Other Names||E3 ubiquitin-protein ligase NRDP1, 632-, RING finger protein 41, RNF41, FLRF, NRDP1|
|Target/Specificity||RNF41 (NP_005776, 218 a.a. ~ 317 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||RNF41 Antibody (monoclonal) (M01A) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.
Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells. Chen L, et al. Cancer Res, 2010 Jul 15. PMID 20587519.Apollon/RNF41 myocardial messenger RNA diagnoses cardiac allograft apoptosis in rejection. Aharinejad S, et al. Transplantation, 2010 Jan 27. PMID 20098290.Genetic screening for mutations in the Nrdp1 gene in Parkinson disease patients in a Chinese population. Mo X, et al. Parkinsonism Relat Disord, 2010 Mar. PMID 19800834.Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress. Yu F, et al. Neurosci Lett, 2008 Jul 25. PMID 18541373.Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Cao Z, et al. Mol Cell Biol, 2007 Mar. PMID 17210635.
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