RNUT1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant RNUT1.
|Application ||WB, IF|
|Calculated MW||41143 Da|
|Other Names||Snurportin-1, RNA U transporter 1, SNUPN, RNUT1, SPN1|
|Target/Specificity||RNUT1 (AAH04203, 1 a.a. ~ 360 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||RNUT1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
Molecular determinants of snurportin 1 ligand affinity and structural response upon binding. Goette M, et al. Biophys J, 2009 Jul 22. PMID 19619473.Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP. Monecke T, et al. Science, 2009 May 22. PMID 19389996.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.Cross-talk between snurportin1 subdomains. Ospina JK, et al. Mol Biol Cell, 2005 Oct. PMID 16030253.Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. Strasser A, et al. EMBO J, 2005 Jul 6. PMID 15920472.
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