RTN2 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant RTN2.
|Calculated MW||59264 Da|
|Other Names||Reticulon-2, Neuroendocrine-specific protein-like 1, NSP-like protein 1, Neuroendocrine-specific protein-like I, NSP-like protein I, NSPLI, RTN2, NSPL1|
|Target/Specificity||RTN2 (NP_005610, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||RTN2 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.
Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4. Ikemoto T, et al. Diabetes, 2009 Dec. PMID 19720795.Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. Liu Y, et al. J Biol Chem, 2008 Mar 7. PMID 18096700.Phosphoproteomic analysis of the developing mouse brain. Ballif BA, et al. Mol Cell Proteomics, 2004 Nov. PMID 15345747.Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation. He W, et al. Nat Med, 2004 Sep. PMID 15286784.Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. Reuter TY, et al. Exp Cell Res, 2003 Oct 1. PMID 14499622.
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