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S100A13 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant S100A13.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q99584 |
| Other Accession | NM_005979 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3A7 |
| Calculated MW | 11471 Da |
| Gene ID | 6284 |
|---|---|
| Other Names | Protein S100-A13, S100 calcium-binding protein A13, S100A13 |
| Target/Specificity | S100A13 (NP_005970, 1 a.a. ~ 98 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | S100A13 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
References
S100A13 is a new angiogenic marker in human melanoma. Massi D, et al. Mod Pathol, 2010 Jun. PMID 20208480.S100A13-C2A binary complex structure-a key component in the acidic fibroblast growth factor for the non-classical pathway. Mohan SK, et al. Biochem Biophys Res Commun, 2009 Mar 13. PMID 19284995.Structure of calcium-bound human S100A13 at pH 7.5 at 1.8 A resolution. Imai FL, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 Feb 1. PMID 18259052.Crystal structure study on human S100A13 at 2.0 A resolution. Li M, et al. Biochem Biophys Res Commun, 2007 May 11. PMID 17374362.Crystallization and preliminary X-ray analysis of human S100A13. Imai FL, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Nov 1. PMID 17077500.
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