S100A7 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full-length recombinant S100A7.
|Application ||WB, IF, E|
|Calculated MW||11471 Da|
|Other Names||Protein S100-A7, Psoriasin, S100 calcium-binding protein A7, S100A7, PSOR1, S100A7C|
|Target/Specificity||S100A7 (AAH34687.1, 1 a.a. ~ 101 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||S100A7 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known.
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. Tieu DD, et al. J Allergy Clin Immunol, 2010 Mar. PMID 20226301.S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer. West NR, et al. Oncogene, 2010 Apr 8. PMID 20101226.Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding. West NR, et al. Protein Sci, 2009 Dec. PMID 19844956.Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways. Le?n R, et al. Biochemistry, 2009 Nov 10. PMID 19810752.
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