SAA1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SAA1.
|Application ||WB, IHC|
|Calculated MW||13532 Da|
|Other Names||Serum amyloid A-1 protein, SAA, Amyloid protein A, Amyloid fibril protein AA, Serum amyloid protein A(2-104), Serum amyloid protein A(3-104), Serum amyloid protein A(2-103), Serum amyloid protein A(2-102), Serum amyloid protein A(4-101), SAA1|
|Target/Specificity||SAA1 (AAH07022, 1 a.a. ~ 122 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SAA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn s disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.
[Distribution of genetic polymorphisms of serum amyloid protein A1 in healthy Chinese Han and Uighur populations in Xinjiang.] Xie X, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2010 Aug. PMID 20677144.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Serum amyloid A is elevated in the serum of lung cancer patients with poor prognosis. Cho WC, et al. Br J Cancer, 2010 Jun 8. PMID 20502455.Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. Kramer HB, et al. PLoS Pathog, 2010 May 6. PMID 20463814.Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCID mouse chimera model. Connolly M, et al. J Immunol, 2010 Jun 1. PMID 20435930.
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