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SETDB1 Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant SETDB1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q15047 |
| Other Accession | NM_012432 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4A3 |
| Calculated MW | 143157 Da |
| Gene ID | 9869 |
|---|---|
| Other Names | Histone-lysine N-methyltransferase SETDB1, ERG-associated protein with SET domain, ESET, Histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, Lysine N-methyltransferase 1E, SET domain bifurcated 1, SETDB1, KIAA0067, KMT1E |
| Target/Specificity | SETDB1 (NP_036564, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SETDB1 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.
References
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Mavaddat N, et al. Cancer Epidemiol Biomarkers Prev, 2009 Jan. PMID 19124506.Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR. Van Duyne R, et al. Retrovirology, 2008 May 22. PMID 18498648.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression. Gao H, et al. Mol Cell Biochem, 2007 Nov. PMID 17577629.ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Ryu H, et al. Proc Natl Acad Sci U S A, 2006 Dec 12. PMID 17142323.
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