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SETDB1 Antibody (monoclonal) (M07)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT3832a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
SETDB1 Antibody (monoclonal) (M07) - Product info | |
| Application | IF, WB
|
| Primary Accession | Q15047 |
| Other Accession | NP_036564 |
| Reactivity | Human |
| Concentration | 1 mg/ml |
| Isotype | IgG2a Kappa |
| Clone Names | 4A3 |
| Calculated MW | 143157 Da |
SETDB1 Antibody (monoclonal) (M07) - Additional info | |
| Gene ID 9869 | |
| Other Names ESET, KG1T, KIAA0067SET domain, bifurcated 1 | |
| Target/Specificity SETDB1 (NP_036564, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SETDB1 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SETDB1 Antibody (monoclonal) (M07) - Related products
AP1073a: SETDB1 Antibody (N-term)
AP1073b: SETDB1 Antibody (C-term)
RI14798: SETDB1 predesign siRNA
BP1073a: SETDB1 Antibody (N-term) Blocking Peptide
SETDB1 Antibody (monoclonal) (M07) - Application data
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Immunofluorescence of monoclonal antibody to SETDB1 (AT3832a) on HeLa cell . [antibody concentration 10 ug/ml]
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SETDB1 monoclonal antibody (M07), clone 4A3 Western Blot analysis of SETDB1 expression in SW-13 ( Cat # L005V1 ).
SETDB1 Antibody (monoclonal) (M07) - Research Areas
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BACKGROUND
This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.
REFERENCES
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Mavaddat N, et al. Cancer Epidemiol Biomarkers Prev, 2009 Jan. PMID 19124506.Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR. Van Duyne R, et al. Retrovirology, 2008 May 22. PMID 18498648.Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression. Gao H, et al. Mol Cell Biochem, 2007 Nov. PMID 17577629.ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Ryu H, et al. Proc Natl Acad Sci U S A, 2006 Dec 12. PMID 17142323.
