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SETX Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant SETX.

  • WB - SETX Antibody (monoclonal) (M05) AT3834a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.52 KDa) .
  • WB - SETX Antibody (monoclonal) (M05) AT3834a
    SETX monoclonal antibody (M05), clone 2A9. Western Blot analysis of SETX expression in PC-12((Cat # AT3834a )
  • WB - SETX Antibody (monoclonal) (M05) AT3834a
    SETX monoclonal antibody (M05), clone 2A9. Western Blot analysis of SETX expression in NIH/3T3((Cat # AT3834a )
  • IF - SETX Antibody (monoclonal) (M05) AT3834a
    Immunofluorescence of monoclonal antibody to SETX on HeLa cell. [antibody concentration 10 ug/ml]
  • E - SETX Antibody (monoclonal) (M05) AT3834a
    Detection limit for recombinant GST tagged SETX is 0.3 ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z333
Other Accession NM_015046
Reactivity Human, Mouse, Rat
Host mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 2A9
Calculated MW 302880 Da
Additional Information
Gene ID 23064
Other Names Probable helicase senataxin, 364-, Amyotrophic lateral sclerosis 4 protein, SEN1 homolog, SETX, ALS4, KIAA0625, SCAR1
Target/Specificity SETX (NP_055861.2, 2579 a.a. ~ 2676 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSETX Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).


Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Exon deletions and intragenic insertions are not rare in ataxia with oculomotor apraxia 2. Bernard V, et al. BMC Med Genet, 2009 Sep 11. PMID 19744353.Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin. Airoldi G, et al. Neurogenetics, 2010 Feb. PMID 19593598.Ataxia with oculomotor apraxia type 2: novel mutations in six patients with juvenile age of onset and elevated serum alpha-fetoprotein. Bernard V, et al. Neuropediatrics, 2008 Dec. PMID 19569000.Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Suraweera A, et al. Hum Mol Genet, 2009 Sep 15. PMID 19515850.

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$ 315.00
Cat# AT3834a
(40 western blots)
Availability: 7-10 days
Bulk Size
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