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SETX Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant SETX.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q7Z333 |
| Other Accession | NM_015046 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2A9 |
| Calculated MW | 302880 Da |
| Gene ID | 23064 |
|---|---|
| Other Names | Probable helicase senataxin, 364-, Amyotrophic lateral sclerosis 4 protein, SEN1 homolog, SETX, ALS4, KIAA0625, SCAR1 |
| Target/Specificity | SETX (NP_055861.2, 2579 a.a. ~ 2676 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SETX Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4).
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Exon deletions and intragenic insertions are not rare in ataxia with oculomotor apraxia 2. Bernard V, et al. BMC Med Genet, 2009 Sep 11. PMID 19744353.Characterization of two novel SETX mutations in AOA2 patients reveals aspects of the pathophysiological role of senataxin. Airoldi G, et al. Neurogenetics, 2010 Feb. PMID 19593598.Ataxia with oculomotor apraxia type 2: novel mutations in six patients with juvenile age of onset and elevated serum alpha-fetoprotein. Bernard V, et al. Neuropediatrics, 2008 Dec. PMID 19569000.Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Suraweera A, et al. Hum Mol Genet, 2009 Sep 15. PMID 19515850.
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