SGCB Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant SGCB.
|Application ||WB, IHC, IF, E|
|Calculated MW||34777 Da|
|Other Names||Beta-sarcoglycan, Beta-SG, 43 kDa dystrophin-associated glycoprotein, 43DAG, A3b, SGCB|
|Target/Specificity||SGCB (NP_000223, 87 a.a. ~ 196 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SGCB Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.
Sarcoglycanopathies: can muscle immunoanalysis predict the genotype? Klinge L, et al. Neuromuscul Disord, 2008 Dec. PMID 18996010.Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation. Sharma P, et al. Am J Physiol Lung Cell Mol Physiol, 2008 Jan. PMID 17993586.The beta-delta-core of sarcoglycan is essential for deposition at the plasma membrane. Draviam RA, et al. Muscle Nerve, 2006 Dec. PMID 17036316.Muscle protein analysis in the detection of heterozygotes for recessive limb girdle muscular dystrophy type 2B and 2E. Fanin M, et al. Neuromuscul Disord, 2006 Nov. PMID 16934466.Homozygous microdeletion of chromosome 4q11-q12 causes severe limb-girdle muscular dystrophy type 2E with joint hyperlaxity and contractures. Kaindl AM, et al. Hum Mutat, 2005 Sep. PMID 16088906.
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