SHMT1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SHMT1.
|Application ||WB, IHC, E|
|Calculated MW||53083 Da|
|Other Names||Serine hydroxymethyltransferase, cytosolic, SHMT, Glycine hydroxymethyltransferase, Serine methylase, SHMT1|
|Target/Specificity||SHMT1 (NP_004160, 374 a.a. ~ 482 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SHMT1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. Porter KE, et al. Environ Res, 2010 Aug. PMID 20670920.Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Levine AJ, et al. Cancer Epidemiol Biomarkers Prev, 2010 Jul. PMID 20615890.Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. Summers CM, et al. Birth Defects Res A Clin Mol Teratol, 2010 Aug. PMID 20544798.Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. Vijayakrishnan J, et al. Haematologica, 2010 Aug. PMID 20511665.
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