SIGIRR Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SIGIRR.
|Calculated MW||45679 Da|
|Other Names||Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, Single immunoglobulin domain-containing IL1R-related protein, Toll/interleukin-1 receptor 8, TIR8, SIGIRR|
|Target/Specificity||SIGIRR (AAH03591, 1 a.a. ~ 410 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SIGIRR Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis. Drexler SK, et al. Arthritis Rheum, 2010 Aug. PMID 20506350.Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. Mosbruger TL, et al. J Infect Dis, 2010 May 1. PMID 20331378.The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. Khan MA, et al. J Immunol, 2010 Mar 1. PMID 20130217.TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. Garlanda C, et al. Trends Immunol, 2009 Sep. PMID 19699681.Gene polymorphisms of Toll-like and related recognition receptors in relation to the vaginal carriage of Gardnerella vaginalis and Atopobium vaginae. Verstraelen H, et al. J Reprod Immunol, 2009 Jan. PMID 19200604.
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