SLBP Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SLBP.
|Application ||WB, IF|
|Calculated MW||31286 Da|
|Other Names||Histone RNA hairpin-binding protein, Histone stem-loop-binding protein, SLBP, HBP|
|Target/Specificity||SLBP (AAH14908, 1 a.a. ~ 270 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SLBP Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1.
1.Destabilization of CDC6 upon DNA damage is dependent on neddylation but independent of Cullin E3 ligases.Tan CY, Hagen TInt J Biochem Cell Biol. 2013 Apr 15;45(7):1489-1498. doi: 10.1016/j.biocel.2013.04.010.
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