SLC15A1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SLC15A1.
|Application ||WB, E|
|Calculated MW||78806 Da|
|Other Names||Solute carrier family 15 member 1, Intestinal H(+)/peptide cotransporter, Oligopeptide transporter, small intestine isoform, Peptide transporter 1, SLC15A1, PEPT1|
|Target/Specificity||SLC15A1 (NP_005064, 473 a.a. ~ 572 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SLC15A1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.
The apical (hPepT1) and basolateral peptide transport systems of Caco-2 cells are regulated by AMP-activated protein kinase. Pieri M, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Jul. PMID 20430871.L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. Yokoyama K, et al. Nephron Clin Pract, 2010. PMID 20424473.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Transport of the advanced glycation end products alanylpyrraline and pyrralylalanine by the human proton-coupled peptide transporter hPEPT1. Geissler S, et al. J Agric Food Chem, 2010 Feb 24. PMID 20104847.The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters. Geissler S, et al. FEBS J, 2010 Feb. PMID 20067523.
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