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SLC26A5 Antibody (monoclonal) (M04)

Mouse monoclonal antibody raised against a partial recombinant SLC26A5.

  • WB - SLC26A5 Antibody (monoclonal) (M04) AT3916a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.78 KDa) .
  • E - SLC26A5 Antibody (monoclonal) (M04) AT3916a
    Detection limit for recombinant GST tagged SLC26A5 is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P58743
Other Accession NM_198999
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 1F4
Calculated MW 81264 Da
Additional Information
Gene ID 375611
Other Names Prestin, Solute carrier family 26 member 5, SLC26A5, PRES
Target/Specificity SLC26A5 (NP_945350, 645 a.a. ~ 742 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSLC26A5 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.


Genotyping with a 198 mutation arrayed primer extension array for hereditary hearing loss: assessment of its diagnostic value for medical practice. Rodriguez-Paris J, et al. PLoS One, 2010 Jul 26. PMID 20668687.Structure of the cytosolic portion of the motor protein prestin and functional role of the STAS domain in SLC26/SulP anion transporters. Pasqualetto E, et al. J Mol Biol, 2010 Jul 16. PMID 20471983.Cysteine mutagenesis reveals transmembrane residues associated with charge translocation in prestin. McGuire RM, et al. J Biol Chem, 2010 Jan 29. PMID 19926791.Mutation-induced reinforcement of prestin-expressing cells. Kumano S, et al. Biochem Biophys Res Commun, 2009 Nov 27. PMID 19737539.Structural rearrangements of the motor protein prestin revealed by fluorescence resonance energy transfer. Gleitsman KR, et al. Am J Physiol Cell Physiol, 2009 Aug. PMID 19515900.

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$ 315.00
Cat# AT3916a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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