SLC9A1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SLC9A1.
|Application ||WB, IHC, E|
|Calculated MW||90763 Da|
|Other Names||Sodium/hydrogen exchanger 1, APNH, Na(+)/H(+) antiporter, amiloride-sensitive, Na(+)/H(+) exchanger 1, NHE-1, Solute carrier family 9 member 1, SLC9A1, APNH1, NHE1|
|Target/Specificity||SLC9A1 (AAH12121, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SLC9A1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others (Mattei et al., 1988 [PubMed 2846238]).
Upregulation of Na+/H+ exchanger by the AMP-activated protein kinase. Rotte A, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20609358.NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance. Lauritzen G, et al. Exp Cell Res, 2010 Sep 10. PMID 20542029.Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells. Holthouser KA, et al. Am J Physiol Renal Physiol, 2010 Jul. PMID 20427472.Inhibition of Na(+)/H(+) exchanger 1 by 5-(N-ethyl-N-isopropyl) amiloride reduces hypoxia-induced hepatocellular carcinoma invasion and motility. Yang X, et al. Cancer Lett, 2010 Sep 28. PMID 20338684.Activation of Na+/H+ exchanger 1 by neurotensin signaling in pancreatic cancer cell lines. Olszewski U, et al. Biochem Biophys Res Commun, 2010 Mar 12. PMID 20138826.
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