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SMAD3 Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant SMAD3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P84022 |
| Other Accession | NM_005902 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1C11 |
| Calculated MW | 48081 Da |
| Gene ID | 4088 |
|---|---|
| Other Names | Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3 |
| Target/Specificity | SMAD3 (NP_005893, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SMAD3 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
References
Common genetic polymorphisms in Moyamoya and atherosclerotic disease in Europeans. Roder C, et al. Childs Nerv Syst, 2010 Aug 6. PMID 20694560.Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. Jugessur A, et al. PLoS One, 2010 Jul 9. PMID 20634891.Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Valdes AM, et al. Arthritis Rheum, 2010 Aug. PMID 20506137.Single-nucleotide polymorphisms in SMAD3 are associated with chronic obstructive pulmonary disease. Yang T, et al. Exp Biol Med (Maywood), 2010 May. PMID 20463300.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
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